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A mixed-model covariance does not imply MAR dropout

Statement refuted

It is false that a correct random-intercept covariance model for a complete two-visit response vector implies dropout after the first visit is missing at random (MAR).

Facts & Assumptions

Given: A finite probability space with independent signs b,ε1,ε2∈{−1,1}, each taking its two values with probability 1/2.

[F1]

The finite-dimensional mixed model requires finite second moments, zero means, and the stated covariance and independence conditions; it imposes no Gaussianity. Finite-dimensional linear mixed model with explicit longitudinal roles.

[F2]

The marginal covariance is ZGZT+R. Marginal covariance of the linear mixed model.

[F3]

MAR requires the observation-pattern probability to depend on the full response only through the coordinates observed under that pattern. Longitudinal observation patterns and missingness mechanisms.

[F4]

A deterministic observation mechanism is a measurable map from the full state to the recorded observation; a stochastic mechanism is a probability kernel with measurable event probabilities. Scientific statistical model contracts.

[A1]

There is one subject, two scheduled visits, no observed covariates (equivalently, the covariate space is a singleton), X=02×1, Z=(1,1)T, b has variance 1, and ε=(ε1,ε2)T has covariance I2.

Construction

Let μ=0 and set Y1=b+ε1,Y2=b+ε2. Observe Y1 for every subject. Let M2=1 mean the second visit is observed, and specify the observation mechanism M2=1{Y2=2}.

Verification

Given: The finite model and observation mechanism in the Counterexample.

1.1F1F2A1

The signs are centered, square-integrable, and independent; b is independent of ε. Thus this is a moment-only random-intercept mixed model with G=[1] and R=I2. By [F2], its complete-response covariance is Cov⁡(Y1Y2)=(1111)+I2=(2112).

1.2F4givenalgebra

Let the pattern space be R={0,1}2 with its power-set σ-algebra, and define the full observation-pattern map O(y1,y2)=(1,1{y2=2}). It is Borel measurable because its first coordinate is constant and its second is the indicator of a Borel set. The induced kernel K(y,A)=1{O(y)∈A} is the point mass at O(y) for each y; for every A⊆R, y↦K(y,A) is measurable as the indicator of the Borel set O−1(A). Thus [F4] applies. Each sign triple has probability 1/8. The two supported states (1,−1,−1) and (1,−1,1) both give observed first-visit value Y1=0, but their second-visit values are Y2=0 and Y2=2, respectively; their patterns are (1,0) and (1,1).

2.1F3step 1.1step 1.2∎

For the missing-visit pattern r=(1,0), the mechanism probability is 1 at (Y1,Y2)=(0,0) and 0 at (0,2). These supported full-data points have the same observed coordinates Yobs(r)=Y1=0, so this pattern probability cannot depend only on the observed data for r. By [F3], the mechanism is not MAR, despite the correct random-intercept covariance in step 1.1.

Remarks

The example declares the full response law and the dropout kernel separately, as required by Scientific statistical model contracts. The covariance identity constrains only the response law.

Depends on

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