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Positive covariance does not imply PRDS

Statement refuted

Positive pairwise covariance of valid p-values is sufficient for their joint law to be PRDS on the true-null coordinates.

Facts & Assumptions

Given: A finite statistical experiment, two p-value statistics, and both null hypotheses true at its only parameter value.

[F1]

Statistical experiments: an experiment is a measurable sample space, a parameter-label set, and a probability law for each parameter.

[F2]

Valid p-values: a p-value statistic is a measurable map from the sample space into [0,1].

[F3]

Null-valid p-values and familywise and false-discovery error rates: a p-value is valid for a null when P(pi≤u)≤u for every u∈[0,1] under each parameter in that null.

[F4]

Positive regression dependence on true-null coordinates (PRDS): PRDS requires conditional probabilities of every coordinatewise increasing Borel set to have a nondecreasing version on the support of each true-null coordinate.

[F5]

Conditional law given a random element: a conditional-law kernel satisfies ∫AK(x,D) PP1(dx)=P(P1∈A, P∈D) for Borel A,D.

[A1]

Let Ω={ω1,ω2,ω3,ω4} with its power-set sigma-algebra, let Θ={θ0}, and assign probabilities 1/10,1/5,2/5,3/10 to the four states. Set both null hypotheses equal to Θ and define the p-values by the following state table:

StateProbability under θ0p1p2
ω11/101/51/5
ω21/53/54/5
ω32/54/53/5
ω43/1011
[A2]

The PRDS statement uses the standard-Borel conditional-law interface stated under the Axiom of Choice (The Axiom of Choice); the finite positive-mass conditional probabilities below are forced for every version.

Counterexample

1.1F1F2F3A1algebra

The four probabilities in [A1] sum to one, so they define the sampling law of a one-parameter experiment [F1]. Since the sample space is finite with its power-set sigma-algebra, each table coordinate is a measurable [0,1]-valued map and hence a p-value statistic by [F2]. The marginal masses of p1 at 1/5,3/5,4/5,1 are 1/10,1/5,2/5,3/10, giving cumulative probabilities 1/10,3/10,7/10,1. Those are at most their corresponding support values. Between consecutive support values the cumulative probability stays fixed at the preceding value, and below 1/5 it is zero; thus Pθ0(p1≤u)≤u for every u∈[0,1]. For p2, the masses at 1/5,3/5,4/5,1 are 1/10,2/5,1/5,3/10, giving cumulative probabilities 1/10,1/2,7/10,1, again at most the support values and hence at most every intervening u. Both p-values are valid by [F3].

1.2A1algebra

Direct summation in [A1] gives E[p1]=19/25, E[p2]=18/25, and E[p1p2]=74/125, hence Cov⁡(p1,p2)=74/125−(19/25)(18/25)=28/625>0. Both marginal laws are nonconstant, so both variances are positive and the Pearson correlation is positive as well.

2.1F4F5A1A2step 1.1step 1.2algebra∎

The support of p1 is {1/5,3/5,4/5,1}, with positive mass at every point. Let D={(x,y)∈[0,1]2:y≥4/5}, a coordinatewise increasing Borel set. At each support point x, [F5] with conditioning event A={x} forces K(x,D)=P(p1=x,(p1,p2)∈D)/P(p1=x) for every conditional-law version. The table makes these conditional probabilities at x=1/5,3/5,4/5,1 equal to 0,1,0,1, respectively. Every version therefore decreases from 1 at 3/5 to 0 at 4/5, violating the monotonicity in [F4] because 3/5<4/5. By steps 1.1 and 1.2, these are valid p-values with positive covariance; thus the law is not PRDS on the true-null set and refutes the statement. It makes no BH FDR claim for this law.

Remarks

The counterexample concerns the dependence premise only. Positive pairwise covariance does not verify the PRDS condition required by the ordinary BH theorem.

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