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Clipping an understated thinning envelope changes the waiting-time law
Statement
Assume Countable Choice and Dependent Choice. Consider the one-state system with one zero-increment channel and constant propensity . Its first marked reaction time has survival . If an implementation incorrectly uses the understated envelope and clips the acceptance probability to , it accepts every rate-one candidate, so its first marked reaction time has survival . These laws differ for every . The specified algorithm requires a valid envelope and does not clip: a detected violation returns invalid-envelope, and the exact-thinning theorem asserts no law under a failed envelope.
Facts & Assumptions
Given: Countable Choice, Dependent Choice, and the one-state time-dependent propensity system above and the candidate-thinning algorithm.
A zero increment is an allowed marked reaction that leaves the state unchanged, while its propensity still contributes to the total event rate. (Finite-channel reaction propensity systems and their generator)
The thinning algorithm requires a supplied envelope certificate, reports a detected violation as invalid-envelope, and does not clip propensities. (Dominating thinning for bounded time-varying propensities)
Under Countable Choice and Dependent Choice, exact thinning conclusions require the certified envelope; if it fails, the theorem asserts no path law. (Dominating thinning has the prescribed reaction law)
Under Countable Choice and Dependent Choice, for a finite-state reaction system with a specified initial state and unlimited event budget, the Gillespie direct method uses an exponential holding time with parameter equal to the total propensity. (Finite-state Gillespie and next-reaction methods have the specified CTMC law)
Proof
The target system has constant total rate ; [F4] therefore gives its first marked-event survival . This is an event even though , by [F1].
A rate-one candidate process has no candidate by time with probability . The clipped rule accepts every candidate, hence its first accepted-event survival is ; for , . Thus clipping changes the event law.
Here , so the required certificate is false. The specified procedure therefore lies outside the theorem's hypothesis and, whenever the violation is evaluated at a candidate, returns invalid-envelope; [F2] expressly forbids continuing by clipping.
Depends on
- The Axiom of Countable Choice ($\mathrm{AC}_\omega$)
- The axiom of dependent choice: a relation in which every element is related to something admits an $\mathbb{N}$-indexed chain
- Dominating thinning for bounded time-varying propensities
- Finite-channel reaction propensity systems and their generator
- Finite-state Gillespie and next-reaction methods have the specified CTMC law
- Dominating thinning has the prescribed reaction law
Used by
Nothing in the library uses this result yet.
Dependency tree · two levels
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Sources
- David F. Anderson and Thomas G. Kurtz, Continuous Time Markov Chain Models for Chemical Reaction Networks (standard reference, not scraped)