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Finite-state Gillespie and next-reaction methods have the specified CTMC law

Statement

Assume Countable Choice and Dependent Choice, and let E be finite with a reaction system from Finite-channel reaction propensity systems and their generator. Fix an initial state x0∈E. Supply the independent random streams required by Gillespie direct method with horizon and budget statuses and Next-reaction method by internal Poisson clocks, and use unlimited reaction-event budgets. Define the reference marked process starting at x0 recursively: at state x, if λ(x)>0, its next reaction time has law Exp⁡(λ(x)) and its channel is independent of that time with probabilities aj(x)/λ(x); if λ(x)=0, it remains at x. Then both algorithms have the law of this reference process on every finite horizon. With a finite event budget, each algorithm instead returns the corresponding reference-process prefix, stopped according to its stated horizon, absorption and budget rules. The process has generator operator (Qf)(x)=∑j:aj(x)>0aj(x)(f(x+νj)−f(x)), absorbing states are handled exactly, and for Λ=max⁡x∈Eλ(x) the expected total reaction count on [0,T] is at most ΛT. A zero-increment channel is still a marked reaction event, but it contributes zero to the state generator.

Facts & Assumptions

Given: Countable Choice, Dependent Choice, a finite state space E, an initial state x0∈E, a finite-channel reaction system, unlimited reaction-event budgets for full-horizon output, and the random input streams with the product laws specified in the algorithm definitions.

[F1]

A propensity system has total rate λ(x) and reaction generator operator Qf(x)=∑j:aj(x)>0aj(x)(f(x+νj)−f(x)). (Finite-channel reaction propensity systems and their generator)

[F2]

Independent unit exponential clocks with rates aj(x) have first-event time Exp⁡(λ(x)), channel probability aj(x)/λ(x), and independent time and channel. (Competing exponential clocks give the reaction event law)

[F3]

The direct method uses one independent unit exponential and one unit-uniform input per event; the next-reaction method uses independent unit exponential increments in its channel clocks. (Gillespie direct method with horizon and budget statuses, Next-reaction method by internal Poisson clocks)

[F4]

Independent unit exponential interarrival times give the ordered event-time density e−T on each finite-window ordered simplex, the rate-one case of the homogeneous Poisson event-time law. (Finite-window homogeneous Poisson construction and ordered event-time density)

[F5]

Under the declared Countable Choice and Dependent Choice assumptions, countable input streams with the required finite-coordinate product laws exist. (Assuming countable and dependent choice, countable products of arbitrary probability spaces)

[F6]

For a finite state space the rate bound Λ is finite; dominating thinning has accepted event count bounded by a rate-Λ Poisson candidate count with expectation ΛT. With the time-constant rates used here, the standard cumulative mark intervals are independent of time and hence have product-measurable time-mark regions, satisfying the exact-thinning theorem's generalized measurability condition. (Dominating thinning has the prescribed reaction law)

[A1]

Countable Choice is used in the exponential and uniform probability laws. (The Axiom of Countable Choice (ACω))

[A2]

Dependent Choice is used in the countable product probability-space construction for the input streams. (The axiom of dependent choice: a relation in which every element is related to something admits an N-indexed chain)

Proof

technique · direct
1.1A1A2F4F5givenalgebra

For one channel clock sequence with independent unit exponential gaps, the joint density of exactly m ordered thresholds 0<s1<⋯<sm≤u and no next threshold by u is ∏i=1me−(si−si−1) e−(u−sm)=e−u,s0=0. This agrees with [F4] at unit rate, so each Yj in the next-reaction construction is a unit-rate Poisson process on finite windows. The streams for distinct channels are independent by [F5], and after an event the unused sequence coordinates remain independent: partition on the finite index of the last used coordinate and use the finite-coordinate product law.

1.2A1F1F2F3givenalgebra

At state x with λ(x)>0, the direct method's waiting time E/λ(x) has survival e−λ(x)t by [F2]. The disjoint cumulative intervals for U have lengths aj(x)/λ(x), so channel j is selected with that probability; because U and E are independent, the channel is independent of the waiting time. Thus the direct method uses exactly the reference event kernel. If λ(x)=0, it returns the absorbing path specified in the Statement.

2.1A1A2F2F3F5step 1.2algebra

At a state x, the next-reaction clock of channel j has residual internal threshold distributed as an independent Exp⁡(1) variable. By [F2] their minimum has the same event-time and channel law as in step 1.2. After a reaction at elapsed time δ, every nonwinning channel k is conditioned only on its threshold exceeding ak(x)δ; memorylessness follows exactly from P(Ek>ak(x)δ+u∣Ek>ak(x)δ)=e−u. The residual thresholds remain independent because the conditioning events factor across independent clocks, and the fired channel receives a fresh independent exponential increment. Induction over the reaction count proves that every successive event kernel agrees with step 1.2, hence the full marked path law agrees. The threshold construction also gives Xt=X0+∑jνjYj(∫0taj(Xs−)ds) by its definition.

3.1F1F2F6step 1.2step 2.1givenalgebra

Apply the bounded-envelope thinning theorem with the time-constant rates aj(t,x)=aj(x) and envelope Λ=max⁡x∈Eλ(x). It gives finitely many events almost surely and EN(T)≤ΛT. For bounded f and small h, the probability of no reaction is e−λ(x)h=1−λ(x)h+O(h2); the probability of exactly one channel-j reaction is aj(x)h+O(h2) by its first-event density; and the probability of two or more is O(h2) by the candidate Poisson bound in [F6]. Therefore lim⁡h↓0Ex[f(Xh)]−f(x)h=∑j:aj(x)>0aj(x)(f(x+νj)−f(x)), which is the operator in [F1]. A zero-increment channel contributes zero to this expression even though its marked event is counted.

4.1step 1.2step 2.1step 3.1given∎

Steps 1.2 and 2.1 identify both algorithmic event kernels, starting at the fixed x0, with the reference kernel; the finite event bound in step 3.1 makes the unlimited-budget comparison a full-horizon path-law equality. A firing at a fixed deterministic horizon has probability zero, since each successive event time has a density conditional on the preceding history; the countable union over event indices is still null. Thus the algorithms' endpoint branches do not alter the path-law conclusion. With a finite budget, the same event-kernel comparison holds up to the algorithm's stopping rule and gives exactly the stated prefix law. Step 3.1 computes the generator and expected event-count bound.

Depends on

Used by

Cited to discharge well-definedness by Next-reaction method by internal Poisson clocks.

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