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Minimum-intensity coupling of reaction networks
Definition
Inputs. Two finite-state reaction systems and with the same finite channel labels . Their state sets may differ, and channel has respective increments and propensities as in Finite-channel reaction propensity systems and their generator. Supply an initial pair , a horizon , and an optional candidate budget , defaulting to , where .
For each channel set These are finite because both state sets are finite. Supply mutually independent and for . The countable input product uses Countable Choice and Dependent Choice; the exponential law is that of Exponential and Weibull survival specifications define probability laws. For the uniform law, Assuming countable choice, is a sigma-algebra containing every elementary set and is a complete measure extending elementary volume makes the set function in Lebesgue measurable sets, the family , and the restricted set function a measure, and A box in with parameters is Lebesgue measurable of measure , whichever of its faces are included gives its restriction to mass one and interval probabilities equal to lengths.
Procedure. Set , , and . If , return the two constant paths through with status absorbed. Otherwise define fixed mark blocks , where and ; omit empty blocks when , and include the endpoint in the last nonempty block. While :
- If , return the pair of path prefixes with status budget-exhausted.
- Set . If , return both paths held through with status horizon.
- Set . Find the unique nonempty block containing and set . Fire channel in if , and fire it in if . If both fire, record a shared event and update both states; if only one fires, record its residual event and update only that state; if neither fires, reject the candidate and leave both states fixed. Increment once for every candidate, including a rejected candidate. Endpoint marks have probability zero, so the last-block convention at does not affect the path law.
The candidate mark block for channel has length . Within it the two acceptance intervals start at the same endpoint and have respective lengths and . Thus their overlap has candidate intensity , and the two residual portions have intensities and . The budget counts candidates, so an exhausted budget returns only an incomplete prefix. No logarithmic event-selection cost is claimed.
Depends on
- Dominating thinning for bounded time-varying propensities
- The Axiom of Countable Choice ($\mathrm{AC}_\omega$)
- The axiom of dependent choice: a relation in which every element is related to something admits an $\mathbb{N}$-indexed chain
- Independent random elements
- Law or distribution of a random element
- Lebesgue measurable sets, the family $\mathcal{L}(\mathbb{R}^n)$, and the restricted set function $\lambda_n$
- Random elements and real random variables
- Finite-channel reaction propensity systems and their generator
- Assuming countable and dependent choice, countable products of arbitrary probability spaces
- Exponential and Weibull survival specifications define probability laws
- A box in $\mathbb{R}^n$ with parameters $a_i\le b_i$ is Lebesgue measurable of measure $\prod_{i<n}(b_i-a_i)$, whichever of its faces are included
- Assuming countable choice, $\mathcal{L}(\mathbb{R}^n)$ is a sigma-algebra containing every elementary set and $\lambda_n$ is a complete measure extending elementary volume
Used by
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Sources
- David F. Anderson, Introduction to Stochastic Processes with Applications to Biology, Chapters 6–7 (standard reference, not scraped)
- David F. Anderson and Thomas G. Kurtz, Continuous Time Markov Chain Models for Chemical Reaction Networks (standard reference, not scraped)