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Cox score martingale representation and random-risk-mean replacement

Statement

Use the IID bounded-covariate model, risk-support hypotheses of Integrated and conditional uniform convergence of Cox risk-set sums, the no-tie event process, and the per-subject counting-process contracts of Simple counting-process intensity and compensator contract. Let zˉ(t)=s(1)(t,β0)s(0)(t,β0),I=∫0τ{s(2)(t,β0)−s(1)(t,β0)s(1)(t,β0)Ts(0)(t,β0)}λ0(t) dt,ξi=∫0τ{Zi(t)−zˉ(t)} dMi(t), where each vector integral is defined coordinatewise in L². If Un(β)=∂βlog⁡Lp(β) is the partial-likelihood score, then n−1/2Un(β0)=n−1/2∑i=1nξi+oP(1). The ξi are IID, centered, square-integrable vectors with covariance matrix I. In particular, n−1/2∑iξi=OP(1). The replacement of the random risk-set mean by zˉ is part of the conclusion.

Facts & Assumptions

Given: The model and integrated risk-set conditions stated above, plus the finite-horizon square-integrable counting-process contracts with continuous compensators, no tied failures, and λ0∈L1[0,τ].

[F1]

Cox proportional-hazards model and partial likelihood: the no-tie partial likelihood is the product of event weights divided by their risk-set weight sums, with Yi(t)=1{Ui≥t}.

[F2]

Integrated and conditional uniform convergence of Cox risk-set sums: defines the empirical and population weighted risk means, sets each to zero at a zero denominator, and proves expected squared-error convergence integrated against λ0(t)dt, with positive empirical denominators uniformly with probability tending to one.

[L1]

Simple counting-process intensity and compensator contract: Mi=Ni−Ai is a square-integrable martingale with continuous compensator Ai(t)=∫0tYi(u)eβ0TZi(u)λ0(u) du under the stated model contract.

[L2]

Elementary predictable integral against a counting-process martingale: for predictable step integrands the stochastic integral is the finite sum of coefficients times martingale increments.

[L3]

Brackets of a compensated simple counting process: Mi2−Ai is a martingale and ⟨Mi⟩=Ai.

[L4]

L² extension of the predictable counting-process integral: a predictable integrand with finite compensator L2 energy has a square-integrable martingale integral with the bracket isometry.

[L5]

Stochastic order and convergence notation for finite-dimensional random vectors: a sequence is OP(1) when it is bounded in probability.

[F3]

Progressively measurable and predictable processes: predictable processes are jointly measurable and deterministic Borel functions of time are predictable.

[F4]

Pathwise identity for bounded predictable counting-process integrals: bounded predictable completed stochastic integrals equal their pathwise dN−dA expressions.

[A1]

AC is inherited from the counting-process and conditional-expectation interfaces. The Axiom of Choice

Proof

technique · Decompose the score using the compensator, cancel its finite-variation part, and bound the random-mean correction by the aggregate counting-process isometry
1.1A1F1F4L1given

Differentiating the finite product in Cox proportional-hazards model and partial likelihood gives Un(β0)=∑i∫0τ{Zi(t)−Zˉn(t,β0)} dNi(t). By [F4], this pathwise integral can be decomposed as the L² stochastic integral and its compensator integral. Writing dNi=dMi+Yieβ0TZiλ0 dt, the compensator contribution is zero because ∑iYi(t)eβ0TZi(t){Zi(t)−Zˉn(t,β0)}=0 whenever the risk denominator is positive; outside the risk set every summand is zero.

2.1A1F1F2F3L1L2L4step 1.1

Set M=∑iMi and Hn(t)=Zˉn(t,β0)−zˉ(t). The process Hn is predictable by [F1]–[F3] and the deterministic measurability of zˉ. For bounded predictable step approximations, the finite-sum definition [L2] is linear in the integrator; the isometry [L4] and A⋅=∑iAi pass that identity to the L² limits. Thus n−1/2Un(β0)=n−1/2∑iξi−n−1/2∫0τHn(t) dM(t). No simultaneous failures make N⋅=∑iNi a simple counting process, and the sum of the subject contracts is a square-integrable martingale contract with compensator A⋅=∑iAi.

3.1F2L1L4step 2.1algebra

The predictable aggregate integrand Hn is bounded by 2K. Its compensator energy satisfies n−1E∫0τ∥Hn(t)∥22 dA⋅(t)=E∫0τ∥Hn(t)∥22Sn(0)(t,β0)λ0(t)dt≤eK∥β0∥2E∫0τ∥Hn(t)∥22λ0(t)dt⟶0 by [F2]'s integrated squared-error conclusion, without a time supremum. Thus [L4] shows the aggregate correction in step 2.1 tends to zero in L² after division by n, and therefore is oP(1).

4.1F1F2F4L3L4L5step 3.1algebra∎

By [F4], ξi equals the event sum minus the compensator Lebesgue integral with integrand Zi−zˉ. Both are measurable functions of the ith subject record and the deterministic function zˉ, so the ξi are IID. The integral isometry gives mean zero. Applying its scalar form to each coordinate and polarizing the identity gives the cross-coordinate isometry, hence E[ξiξiT]=∫0τE[Yi(t)eβ0TZi(t){Zi(t)−zˉ(t)}⊗2]λ0(t) dt=I. The equality follows by expanding the outer product and using zˉ=s(1)/s(0). Independence and centering give E∥n−1/2∑iξi∥22=tr⁡(I). For M>0, nonnegativity gives M2P(∥n−1/2∑iξi∥2>M)≤E∥n−1/2∑iξi∥22=tr⁡(I), so the normalized sum is OP(1) by [L5]. Combining this with step 3.1 proves the representation and the stated moment properties.

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