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Known-covariance GLS is BLUE

Statement

Let the linear mixed model have fixed design X∈Rn×p of full column rank and known marginal covariance V=Cov⁡(Y)≻0. Then β^GLS=(XTV−1X)−1XTV−1Y is unbiased for β, has covariance (XTV−1X)−1, and is BLUE: for every linear unbiased estimator β~ and every c∈Rp, Var⁡(cTβ^GLS)≤Var⁡(cTβ~). Only the fixed-design mean and covariance are used; Gaussianity is not assumed.

Facts & Assumptions

Given: The fixed-design mixed model, full-column-rank X, known V≻0, and the estimator defined in Generalized least-squares estimator for known covariance.

[F1]

The fixed-design mean is EβY=Xβ. Fixed-design linear regression model.

[F2]

The marginal covariance in the moment model is V=ZGZT+R=Cov⁡(Y). Marginal covariance of the linear mixed model.

[F4]

In a full-rank fixed-design model with covariance σ2I for σ2>0, OLS is unbiased and BLUE for every estimable contrast, without Gaussianity. Gauss–Markov theorem for estimable contrasts.

[F5]

Covariance is bilinear in finite linear combinations. Covariance is symmetric and bilinear in finite linear combinations.

[F6]

Expectation is linear on finite sums of integrable random variables. The Lebesgue integral is linear on L1(μ).

[A1]

X has full column rank, and V is the same known symmetric positive-definite covariance under each Pβ.

Proof

Given: The hypotheses in the Statement.

1.1A1F1F2F3F5F6F7algebra

Choose L from [F3] and set Y~=L−1Y and X~=L−1X. The transformed response is Borel by [F7]. Linearity [F6] and [F1] give EβY~=X~β, and covariance bilinearity [F5] with [F2] gives Cov⁡β(Y~)=L−1VL−T=In. Since L is invertible, X~ has full column rank.

2.1A1F3F4step 1.1algebra

OLS on the transformed model is (X~TX~)−1X~TY~=(XTV−1X)−1XTV−1Y=β^GLS, because L−TL−1=V−1. The transformed model meets every hypothesis of [F4], so this estimator is unbiased and each of its linear contrasts has minimum variance among linear unbiased contrasts.

2.2F1F2F5F6step 1.1algebra

Put C=(XTV−1X)−1 and A=CXTV−1. Then AX=Ip, so linearity [F6] and [F1] give Eβ[AY]=β. By [F5] and [F2], Cov⁡β(AY)=AVAT=CXTV−1VV−1XC=C. Here C is symmetric because XTV−1X is symmetric positive definite.

3.1F4step 1.1step 2.1step 2.2∎

Let β~ be any linear unbiased estimator. For each c, cTβ~ is a linear unbiased estimator of cTβ in the transformed model of step 1.1. By [F4] and step 2.1 its variance is at least that of cTβ^GLS. This holds for every c∈Rp, so the covariance difference is positive semidefinite and GLS is BLUE.

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