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Two-stage conditional-error adaptation — Examples
1 · Prerequisites
- Absolute and Conditional Convergence; Rearrangement; Products
- Binary Operations, Monoids, Groups and Subgroups
- Compactness in Metric Spaces
- Completeness, Completion, and Uniform Continuity
- Conditional Expectation
- Construction of the Natural Numbers
- Construction of the Real Numbers via Cauchy Sequences
- Construction of the Real Numbers via Dedekind Cuts
- Continuity, IVT, EVT, and Uniform Continuity
- Cosets, Index and Lagrange's Theorem
- Countability and Uncountability
- Divisibility, Euclidean Domains, Principal Ideal Domains and Unique Factorisation
- Estimators and Randomized Procedures
- Finite Counting, Factorials and Binomial Coefficients
- Foundations of the Real Numbers for Analysis
- Ideals, Quotient Rings and the Isomorphism Theorems for Rings
- Limits of Real Functions
- limsup, liminf, and Subsequential Limits
- Measurable Functions and Simple Approximation
- Measures and Their Basic Properties
- Metric Spaces
- Monotone Functions, Discontinuities, and Continuity Sets
- Monotone Sequences, Bolzano-Weierstrass, and Cauchy Completeness
- Normal Subgroups and Quotient Groups
- Order, Zorn's Lemma, and the Axiom of Choice
- Polynomial Rings, the Division Algorithm and Roots
- Power Series and Real-Analytic Functions
- Probability Spaces Random Variables and Expectation
- Properties of the Integral and the Working FTC
- Relations, Functions, and Quotients
- Rings, Subrings, Integral Domains and Fields
- Roots, Rational Powers, and Classical Inequalities
- Sequences and Limits
- Sequences and Series of Functions; Uniform Convergence
- Series: Convergence and the Nonnegative Tests
- Sigma Algebras and Borel Sets
- Signed and Complex Measures Hahn and Jordan
- Simple Field Extensions and the Construction of the Complex Numbers
- Statistical Experiments, Models and Identifiability
- Suprema and Infima
- Tests, Neyman–Pearson and Valid P-values
- The Derivative and the Mean Value Theorems
- The Exponential Function
- The Lebesgue Integral and the Convergence Theorems
- The Logarithm and General Powers
- The Lᵖ Spaces Holder Minkowski and Riesz Fischer
- The Radon Nikodym Theorem and Lebesgue Decomposition
- The Riemann Integral: Definition and Integrability
- The ZFC Axioms and the Basic Set Constructions
- Topological Spaces and Continuity
- Topology of ℝ
- Triangularisation, Generalised Eigenspaces and Jordan Canonical Form
- Two-stage conditional-error adaptation
- Vector Spaces, Linear Subspaces, Span and Direct Sums
2 · Summary
The worked example uses a finite null model to select one of two stage-2 sample sizes from interim information while retaining the selected-size conditional p-value law; the rejection probability equals the original conditional-error budget. A second calculation uses independent normal stage statistics. Its original equal-weight inverse-normal test has size , while an interim-selected, unit-norm weight rule with an unchanged critical value has size . The calculation shows why normalized weights alone do not replace conditional recalibration.
3 · Logical flowchart
4 · Definitions, theorems and proofs
None yet.
5 · Examples, counterexamples and false statements
Calibrated selected sample size and an uncalibrated weight change
Statement
In the finite null model below, the selected stage-2 sample size is a function of interim information, and each selected-size p-value retains its conditional null calibration. The rejection rule at the original conditional error has null rejection probability , equal to the original budget. In the normal model, for any fixed critical value , the equal-weight inverse-normal rule rejecting when has size . Choosing unit-norm weights from the sign of the interim statistic and retaining raises that probability to .
Facts & Assumptions
Given: AC; a finite uniform null probability space for the first model; independent fair binary coordinates ; and, for the second model, independent standard-normal variables with density , where . Thus is even, continuous, strictly positive, and has total mass one. Write .
AC supplies the conditional-expectation classes inherited by the results used here. The Axiom of Choice
For a countable-valued interim-measurable , calibration within every selected-size stratum implies conditional superuniformity of the selected p-value. Selected-size conditional validity yields a conditionally superuniform p-value
If a stage-2 p-value is conditionally superuniform given , rejection at the original conditional error has conditional rejection probability at most ; when , its overall null rejection probability is at most . A conditionally superuniform stage-2 p-value preserves conditional error
A p-value statistic is measurable, takes values in , and is valid under the null when its null CDF is superuniform. Valid p-values
If an integrable variable is independent of , its conditional expectation given is its ordinary expectation (under AC). Conditioning a known variable and an independent variable
Conditional expectations are almost-sure classes, so changing a version does not alter event probabilities. Conditional expectation as an ae class
Verification
Given: The two null models and notation stated above; verify the calibrated finite-size rejection probability and the changed-weight normal rejection probability.
Put with the uniform law and let be the independent fair-bit coordinates. Define when and when , for . Each is measurable with values in , and its null CDF is for , for , and at , so each is a valid p-value by [F3]. Let , select on and on , and take the original rejection event . Independence and [A1, F4] give its conditional error almost surely; [F5] makes the resulting event probabilities version-independent. For each and , independence of from gives , where for , for , and for ; in every case . Thus [F1] makes conditionally superuniform. Rejection at is exactly the event that the selected bit is zero. Since , set in the overall conclusion of [F2] to obtain ; the selected bit is fair, so equality holds and the original budget is attained.
The positive density makes continuous and strictly increasing. Define the one-sided stage p-values , so ; for , , and the endpoint inequalities are immediate, so they are valid by [F3]. Fix and set , with by positivity and evenness. Under the fixed equal-weight inverse-normal rule, reject when . The orthogonal change of variables , has absolute Jacobian and satisfies , so the joint density transforms to and integration over gives the fixed-rule null rejection probability .
Choose when and when . Without recalibrating , use weights in the first case and in the second; each has squared norm one. Since , the adapted rejection event is the disjoint union , whose probability by independence is . Thus unit-norm weights selected with the stage-2 size do not by themselves preserve the fixed-rule error probability.
Remarks
The normal counterexample uses extreme weights so its size calculation is exact. Sugiura–Uesaka give the more direct sample-size-weight warning: in the weighted inverse-normal rule, replacing the prespecified second-stage size by its interim-selected value can exceed the target null rejection probability. The finite calibrated model above illustrates the separate condition that must be checked: the selected second-stage p-value law under the null.