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Nelson–Aalen, Kaplan–Meier, Greenwood

1 · Prerequisites

2 · Summary

This page defines the pooled risk-set estimators with a fixed event and censoring endpoint convention. Under finite event-time support and positive event and censoring survival, a risk-set proportion argument proves pointwise consistency by induction; the Nelson–Aalen limit is the sum of discrete hazards. Under the stated continuous-time counting-process model contract, the page proves the pointwise influence expansion, its terminal normal limit, and Greenwood's first-order variance consistency. Random risk-set denominators, finite compensator energy, and positive risk support are proved or stated explicitly. Greenwood is not an exact finite-sample variance identity, and no process limit or confidence band is claimed.

3 · Logical flowchart

4 · Definitions, theorems and proofs

DefinitionDefinition: Literature-sourcedProof: Not applicableOpen item page →

Nelson–Aalen, Kaplan–Meier, and Greenwood estimators

Definition

For a positive integer sample size n, let (Ti,Ci), 1≤i≤n, be event and censoring times with right-censored observations (Ui,δi) as in Event-time observation, censoring, and truncation schemes, so Ui=min⁡(Ti,Ci) and δi=1{Ti≤Ci}. The subject counting process and at-risk process are Ni(t)=1{Ui≤t, δi=1} and Yi(t)=1{Ui≥t}. The endpoint convention makes Yi left-continuous at Ui: a subject is still at risk at the observed time, including a tied event and censoring time. Set Nn=∑i=1nNi and Yn=∑i=1nYi. Let dNn be the finite counting measure of observed events on [0,∞), with atom ΔNn(u):=∑i=1n1{Ui=u, δi=1} at each u≥0; in particular, ΔNn(0)=Nn(0). Tied failures at u contribute their full count and censorings at u do not contribute to dNn(u).

For t≥0, the Nelson–Aalen estimator is Λ^n(t)=∫[0,t]1{Yn(u)>0}Yn(u) dNn(u), where the integrand is defined to be zero when Yn(u)=0. The Kaplan–Meier estimator is S^n(t)=∏0≤u≤t:ΔNn(u)>0(1−ΔNn(u)Yn(u)). Each product is finite and a factor is zero if every subject at risk fails at that time. The target survival function is S(t)=P(T>t). If T has density f, S is positive on the horizon, and λ=f/S, the continuous cumulative hazard is Λ(t)=∫0tλ(u) du=−log⁡S(t).

These inclusive endpoint formulas reduce to the usual (0,t] formulas whenever ΔNn(0)=0. If T has finite support 0≤a1<⋯<am, write qj=P(T=aj∣T≥aj); the corresponding discrete cumulative hazard is Λd(t)=∑aj≤tqj. Under IID sampling, independent censoring, and positive risk probability at the support points, the Nelson–Aalen increments estimate these qj; in general this discrete cumulative hazard is not −log⁡S(t).

A baseline event is included at u=0; if it occurs then Ni(0)=1, so a model contract requiring Ni(0)=0 must exclude this case.

An empty event product is 1, and an empty Greenwood event sum is 0.

On a horizon where every event contribution has Yn(u)−ΔNn(u)>0, the Greenwood variance estimate is V^G(t)=S^n(t)2∑0≤u≤t: ΔNn(u)>0ΔNn(u)Yn(u){Yn(u)−ΔNn(u)}. Greenwood's formula is used as a first-order asymptotic variance estimate when the sampling and censoring assumptions justify that approximation; the formula alone asserts no asymptotic result and is not an exact finite-sample variance identity. It is undefined when a contributing denominator is zero.

For each fixed t, Λ^n(t) and S^n(t) are statistics of the observed sample in the sense of Statistics and estimators. Greenwood's formula is a measurable function on the measurable subset Dn(t) of the observed sample space ([0,∞)×{0,1})n where every contributing denominator is positive. Its zero extension V^G∘(t), equal to V^G(t) on Dn(t) and 0 elsewhere, is a statistic on the whole observed sample space. This extension assigns no Greenwood variance interpretation outside Dn(t).

To verify measurability, scan indices i=1,…,n and include only the first event observation at each distinct time in [0,t]; each inclusion condition uses finitely many Borel equalities and inequalities among the observed Ui and δi. Risk and event counts are finite Borel sums. The finitely many positive-denominator tests make Dn(t) measurable; evaluating divisions only on their positive-denominator branches makes the sums, products, and zero extension Borel measurable.

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Finite-support risk-set proportion limits

Statement

For every positive integer sample size n, let (Ti,Ci) be IID subject pairs with Ti independent of Ci, and let the event-time support be 0≤a1<⋯<am. Fix j and suppose P(T≥aj)>0 and P(C≥aj)>0. Put qj=P(T=aj∣T≥aj), rj=P(U≥aj), Yn(aj)=∑i=1n1{Ui≥aj}, and dNn(aj)=∑i=1n1{Ui=aj,δi=1}. Then Yn(aj)/n→Prj=P(T≥aj)P(C≥aj)>0, dNn(aj)/n→PP(T=aj)P(C≥aj), and the ratio dNn(aj)/Yn(aj), set to zero when its denominator is zero, converges in probability to qj.

Facts & Assumptions

Given: The right-censoring convention, IID subject pairs, within-subject independence of T and C, and positive risk probability at aj.

[F1]

Under right censoring, Ui=min⁡(Ti,Ci) and δi=1{Ti≤Ci} (Event-time observation, censoring, and truncation schemes); the at-risk process is Yi(u)=1{Ui≥u} (Nelson–Aalen, Kaplan–Meier, and Greenwood estimators).

[F2]

IID means a common law and mutual independence across the entire subject family. (Identical distribution and IID families)

[A1]

Within each subject, Ti and Ci are independent, and P(T≥aj)P(C≥aj)>0.

Proof

1.1A1F1given

Let Dij=1{Ui=aj,δi=1}. By [F1], Yi(aj)=1{Ti≥aj,Ci≥aj} and Dij=1{Ti=aj,Ci≥aj}. Independence in [A1] therefore gives E[Yi(aj)]=rj=P(T≥aj)P(C≥aj) and E[Dij]=P(T=aj)P(C≥aj).

2.1F2step 1.1algebra

The two indicators are bounded IID sequences by [F2]. For either sequence, the variance of its sample mean is at most 1/(4n), so Chebyshev's inequality gives convergence in probability to its expectation. Since there are finitely many support points, these convergences hold jointly over j=1,…,m.

3.1A1step 2.1algebra∎

Since rj>0, with probability tending to one Yn(aj)/n>rj/2. On that event the ratio is the quotient of the two convergent proportions from step 2.1, and its limit is P(T=aj)P(C≥aj)P(T≥aj)P(C≥aj)=P(T=aj∣T≥aj)=qj. The zero-denominator event has probability tending to zero by the same risk-proportion convergence, so the stated zero convention does not change the limit.

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Finite-support consistency of Nelson–Aalen and Kaplan–Meier

Statement

Let (Ti,Ci) be IID subject pairs with Ti independent of Ci, and suppose the event-time support is 0≤a1<⋯<am. For any fixed t≥0 with S(t)=P(T>t)>0 and P(C≥t)>0, the Kaplan–Meier estimator satisfies S^n(t)→PS(t). The Nelson–Aalen estimator satisfies Λ^n(t)→PΛd(t):=∑aj≤tqj,qj=P(T=aj∣T≥aj). Only event times at or before t enter the products and sums. In a discrete event-time model, Λd(t) is the sum of discrete hazards and is generally not −log⁡S(t).

Facts & Assumptions

Given: IID subjects with right-censored observations Ui=min⁡(Ti,Ci), δi=1{Ti≤Ci}; independent Ti,Ci; finite nonnegative event-time support; and positive event and censoring survival through t. Prove the two stated limits.

[F1]

Right-censored observations are Ui=min⁡(Ti,Ci) and δi=1{Ti≤Ci}. (Event-time observation, censoring, and truncation schemes)

[F2]

For pooled risk and failure counts, Λ^n(t)=∫[0,t]1{Yn(u)>0}Yn(u) dNn(u), with the integrand set to zero when Yn(u)=0, and S^n(t)=∏0≤u≤t:ΔNn(u)>0(1−ΔNn(u)/Yn(u)). A baseline event at a1=0 is included; if a1>0, there is no time-zero event contribution. (Nelson–Aalen, Kaplan–Meier, and Greenwood estimators)

[F3]

At each support point aj through t, the empirical event-to-risk ratio dNn(aj)/Yn(aj) converges in probability to qj. (Finite-support risk-set proportion limits)

[A1]

T and C are independent, event support is finite, and S(t)>0, P(C≥t)>0.

Proof

1.1A1F1F2F3given

Let k be the number of event support points not exceeding t. If k=0, then a1>t≥0, so a1>0 and T>t almost surely; the empty product and sum give the claimed limits. If k≥1, positivity of S(t) and P(C≥t) implies P(T≥aj)P(C≥aj)>0 for every j≤k, so [F3] applies at each of these finitely many points.

1.2A1F1F2F3algebra

Before the first support point, the product is 1=P(T≥a1). After the product limit through aj−1 converges to P(T>aj−1), this equals P(T≥aj) because there is no support in (aj−1,aj). By [F1]–[F2], at aj the product is multiplied by 1−dNn(aj)/Yn(aj) and the sum is incremented by dNn(aj)/Yn(aj). [F3] and continuity of finite products and sums give limits P(T≥aj)(1−qj)=P(T>aj)=S(aj) and ∑ℓ≤jqℓ. This also handles a1=0, since P(T≥0)=1 and the baseline failure increment is included.

2.1step 1.1step 1.2algebra∎

Finite induction over j=1,…,k proves both limits at every support point through t. On each interval between successive support points, the estimators and their targets are constant, so the same limits hold at the given t. The Nelson–Aalen limit is the discrete hazard sum displayed in the statement; the proof does not replace it by a continuous cumulative hazard.

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Uniform convergence of the empirical right-censoring risk set

Statement

Let U1,U2,… be IID real-valued observed times. For every positive integer n, define Yˉn(u)=n−1∑i=1n1{Ui≥u} and s0(u)=P(Ui≥u). For every finite t≥0, sup⁡0≤u≤t∣Yˉn(u)−s0(u)∣→P0,E[sup⁡0≤u≤t∣Yˉn(u)−s0(u)∣2]→0.

Facts & Assumptions

Given: The observed times Ui are IID real random variables; Yi(u)=1{Ui≥u}.

[F1]

The at-risk process is Yi(u)=1{Ui≥u}. (Nelson–Aalen, Kaplan–Meier, and Greenwood estimators)

[F2]

IID means a common law and mutual independence across the whole subject family. (Identical distribution and IID families)

Proof

1.1F1F2algebra

Put Vi=−Ui, let F(x)=P(Vi≤x), and let Fn(x)=n−1∑i=1n1{Vi≤x}. Then Yˉn(u)=Fn(−u) and s0(u)=F(−u). Both CDFs are right-continuous, so their supremum error over R is the supremum over rational x; over [−t,0] it is the supremum over (Q∩[−t,0))∪{0} (with {0} alone when t=0). Thus both suprema are measurable. Fix 0<ε<1. Choose the finitely many distinct quantiles xk=inf⁡{x:F(x)≥kε} for 1≤k<1/ε, together with x0=−∞ and xm+1=+∞, where m is the number of distinct finite cutpoints. Between consecutive distinct quantiles xj<xj+1, the quantile construction gives F(xj+1−)−F(xj)≤ε; any jump at a cutpoint is isolated as its singleton point. At each finite cutpoint, both Fn(xj) and Fn(xj−) converge in probability to their expectations by Chebyshev's inequality applied to the IID indicators 1{Vi≤xj} and 1{Vi<xj}. For x∈(xj,xj+1), monotonicity gives Fn(xj)≤Fn(x)≤Fn(xj+1−) and F(xj)≤F(x)≤F(xj+1−); hence ∣Fn(x)−F(x)∣ is at most the largest one-sided endpoint error plus ε. At singleton cutpoints, direct endpoint convergence applies. Taking the maximum over the finite partition, then n→∞ and ε↓0, proves the first convergence.

2.1step 1.1algebra∎

Let Zn=sup⁡0≤u≤t∣Yˉn(u)−s0(u)∣. Since Zn≤1, for every η>0, E[Zn2]≤η2+P(Zn>η). Step 1.1 makes the second term tend to zero; then letting η↓0 proves the expected-square convergence.

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Pointwise influence limit and Greenwood variance consistency

Statement

Assume the Axiom of Choice. Fix t>0 and, for each positive integer sample size n, observe IID subject pairs (Ti,Ci), with Ti>0 almost surely, Ti independent of Ci, and Ti having an absolutely continuous law on [0,t] with density f. Write S(u)=P(Ti>u)>0, G(u)=P(Ci≥u)>0, and take a finite nonnegative Borel version of λ(u)=f(u)/S(u). Put s0(u)=E[Yi(u)]=P(Ui≥u)=S(u)G(u) for 0≤u≤t. Assume ∫0tλ(u)/s0(u) du<∞. In a common filtration, assume each Yi is predictable and each Mi=Ni−Ai, where Ai(v)=∫0vYi(u)λ(u) du, satisfies the finite-horizon square-integrable counting-process contract. This compensator is a model assumption; a displayed hazard alone is not an existence theorem. Put Λ(t)=∫0tλ(u) du=−log⁡S(t) and σ2(t)=∫0tλ(u)/s0(u) du. Then, with ϕiΛ(t)=∫0ts0(u)−1 dMi(u) and ϕiS(t)=−S(t)ϕiΛ(t), n{Λ^n(t)−Λ(t)}=n−1/2∑i=1nϕiΛ(t)+oP(1),n{S^n(t)−S(t)}=n−1/2∑i=1nϕiS(t)+oP(1). The terminal normal limit is n{S^n(t)−S(t)}⇒N(0,S(t)2σ2(t)). Let V^G∘(t) equal Greenwood's formula on its positive-denominator domain and 0 elsewhere; then nV^G∘(t)→PS(t)2σ2(t)=Var⁡(ϕiS(t)). The extension only defines the sequence on all samples for the convergence statement; it assigns no Greenwood variance interpretation outside the positive-denominator domain. These are fixed-time results; no process convergence or confidence-band conclusion is asserted. Greenwood is not an exact finite-sample variance identity.

Facts & Assumptions

Given: The hypotheses and definitions in the statement, the right-censoring observation scheme, the finite-horizon counting-process model contract, and the Nelson–Aalen, Kaplan–Meier, and Greenwood formulas. Prove the two influence expansions, the terminal normal limit, and Greenwood consistency.

[A1]

Assume the Axiom of Choice (AC), inherited through the counting-process integration and IID terminal-limit suppliers. (The Axiom of Choice)

[F1]

Right-censoring records Ui=min⁡(Ti,Ci) and δi=1{Ti≤Ci}; event ties are recorded as events. (Event-time observation, censoring, and truncation schemes)

[F2]

Yi(u)=1{Ui≥u}, Ni(u)=1{Ui≤u,δi=1}, Λ^n(t)=∫[0,t]1{Yn(u)>0}Yn(u) dNn, with the integrand set to zero when Yn(u)=0, S^n(t)=∏0≤u≤t:ΔNn(u)>0(1−ΔNn(u)/Yn(u)), and Greenwood's formula is defined only when its event denominators are positive. Since Ti>0 almost surely, there is no event at zero under these hypotheses. (Nelson–Aalen, Kaplan–Meier, and Greenwood estimators)

[F3]

The subject records are IID with a common law and mutual independence across subjects. (Identical distribution and IID families)

[F4]

Under the counting-process contract, Ai is continuous predictable with E[Ai(t)]<∞, and Mi=Ni−Ai is a square-integrable martingale; an intensity display alone supplies no existence theorem. (Simple counting-process intensity and compensator contract)

[F5]

For a compensated simple counting process, M2−A is a martingale and ⟨M⟩=A. (Brackets of a compensated simple counting process)

[F6]

The L² counting-process integral is defined by completion for predictable H with E∫0tH2 dA<∞. (L² counting-process integral when the limit exists)

[F7]

On this finite-energy domain the integral is a square-integrable martingale and satisfies E(∫0tH dM)2=E∫0tH2 dA. (L² extension of the predictable counting-process integral)

[F8]

Yˉn(u)=n−1∑i1{Ui≥u} converges uniformly in probability to s0(u) on [0,t], and its expected squared uniform error tends to zero. (Uniform convergence of the empirical right-censoring risk set)

[F9]

If IID subjects have a centered square-integrable measurable influence function and an already-proved oP(n−1/2) expansion remainder, the estimator has the corresponding terminal normal limit; the theorem assumes and does not prove the expansion. (IID terminal influence limit from a separately established expansion)

[F10]

If n(Tn−θ)⇒Z and g is differentiable at θ, then n{g(Tn)−g(θ)}⇒g′(θ)Z in the scalar case. (First- and second-order delta method for random vectors)

[F11]

Predictability is measurability for the predictable sigma-algebra; Borel transformations of predictable processes and deterministic Borel time functions remain predictable. (Progressively measurable and predictable processes)

[F12]

For a nonnegative product-measurable function on a sigma-finite product, Tonelli permits integration in either order. (Tonelli's theorem for nonnegative measurable functions on a sigma-finite product)

[F13]

Pointwise convergence under an integrable majorant gives convergence of integrals. (Dominated convergence)

Proof

1.1givenalgebra

Independence within a subject gives s0(u)=P(Ti≥u,Ci≥u)=S(u)G(u). On [0,t], s0(u)≥c:=S(t)G(t)>0. Since S is absolutely continuous and S′(u)=−f(u)=−λ(u)S(u) almost everywhere, integration of (log⁡S)′=−λ gives Λ(t)=−log⁡S(t). The assumed integral makes σ2(t) finite and also gives ∫0tλ(u) du<∞.

1.2A1F1F2F3F4F5F11givenalgebra

For each finite n, event times have no ties in (0,t] almost surely: for i≠j, subject independence and the absolutely continuous law on [0,t] give P(Ti=Tj≤t)=0, and there are finitely many pairs. Thus Nn=∑iNi is a simple counting process. Set Yn=∑iYi, An=∑iAi=∫0⋅Yn(u)λ(u) du, and Mn=∑iMi=Nn−An. Finite sums preserve the martingale property and square integrability; [F4] gives E[An(t)]=∑iE[Ai(t)]<∞. The process Jn=1{Yn>0} is predictable, and so is ηn=Ynλ by [F11]; both meet [F4]'s domain, with An=∫0⋅Jn(u)ηn(u) du. Hence the pooled process also satisfies the finite-horizon contract. By [F5], its predictable bracket is An.

2.1F1F2F4F6F7F11F13step 1.1step 1.2construct

We will identify the completed integrals with pathwise finite-variation integrals for every bounded predictable integrand H used below. The paths of Yi and Yˉn are left-continuous on (0,t], and s0(u)=P(Ui≥u) is left-continuous there by continuity of probabilities along decreasing events. Consequently s0−1, the floored reciprocal bn, its difference Hn, and the floored product reciprocal qn below all have bounded left-continuous paths, with a deterministic bound for each fixed n. On deterministic partitions with mesh tending to zero, take the left-step approximants H(m)(u)=H(tj) on (tj,tj+1] and set their time-zero value to zero. They are elementary predictable integrands, converge pointwise to H at every u>0, and retain the bound. For any subject or pooled contract, [F13] for the finite compensator measure E dA gives E∫0t∣H(m)−H∣2dA→0, and [F7] gives convergence of their elementary integrals to the completed integral in L2(P). The paths of M=N−A have finite variation; [F13] applied pathwise to its finite variation measure gives convergence of the same elementary sums to ∫(0,t]H dN−∫0tH dA. Uniqueness of limits in probability identifies these two limits almost surely at the fixed time. The time-zero convention is immaterial because N0=A0=0 and A is continuous. This proves the pathwise identities needed below without assuming a general semimartingale integration theorem.

2.2F2F4F8F11step 1.1algebra

Write Yˉn=Yn/n. By [F8], E[sup⁡u≤t∣Yˉn(u)−s0(u)∣2]→0. Let bn(u)=1/max⁡(Yˉn(u),c/2) and Hn(u)=bn(u)−1/s0(u). These are bounded predictable processes: Yˉn is predictable by [F4], and Borel transformations preserve predictability by [F11]. The reciprocal map with floor c/2 is 4/c2-Lipschitz, so E[sup⁡u≤t∣Hn(u)∣2]→0.

3.1F2F6F7F8F11step 1.1step 1.2step 2.1step 2.2algebra

The energy of Hn for Mn is finite because Hn is bounded and E[An(t)]<∞. Applying [F7] to the pooled contract gives E∣n−1/2∫0tHn dMn∣2=n−1E∫0tHn2 dAn=E∫0tHn2Yˉnλ du≤(∫0tλ du)E[sup⁡u≤t∣Hn(u)∣2]→0. Thus this stochastic-integral remainder is oP(1). On the event En={sup⁡u≤t∣Yˉn(u)−s0(u)∣<c/2}, whose probability tends to one by [F8], Yn(u)>0 throughout and bn=1/Yˉn. By the pathwise identification in step 2.1, dNˉn=Yˉnλ du+dMˉn gives there n(Λ^n−Λ)=n−1/2∫0tbn dMn. For each bounded predictable step integrand, the finite-sum definition in [F6] makes the integral against Mn=∑iMi equal to the sum of the subject integrals. Approximate s0−1 in the pooled compensator energy by such steps; [F7] gives L² convergence, and dAi≤dAn lets the same approximants converge for each of the finitely many subjects. Since s0−1 is a deterministic Borel time function, it is predictable by [F11]. Passing the finite-sum identity to these L² limits yields n(Λ^n−Λ)=n−1/2∑i=1n∫0ts0−1 dMi+oP(1).

4.1A1F1F2F3F4F7F9F11F12step 2.1step 3.1algebra

For one subject, step 2.1 identifies the integral in step 3.1 as ϕiΛ(t)=1{δi=1,Ui≤t}/s0(Ui)−∫0Ui∧tλ(u)/s0(u) du, so it is a measurable function of (Ti,Ci). It has mean zero by the martingale property and, by [F7] and Tonelli [F12], variance E∫0ts0(u)−2 dAi(u)=∫0ts0(u)−2E[Yi(u)]λ(u) du=∫0tλ(u)/s0(u) du=σ2(t). The integrand is nonnegative and product-measurable because Yi is predictable and s0−2λ is a deterministic Borel function. Hence these influence variables are IID and square-integrable. The normalized IID sum is bounded in probability by its fixed second moment, so step 3.1 gives a separately established expansion with oP(n−1/2) remainder. Applying [F9] proves n(Λ^n−Λ)⇒N(0,σ2(t)).

5.1F2F10step 3.1step 4.1algebra

On En, for all sufficiently large n, every event jump has size x=1/Yn(u)≤2/(nc)≤1/2. For 0≤x≤1/2, the power series for −log⁡(1−x)−x gives ∣log⁡(1−x)+x∣≤x2. There are at most n event jumps, so ∣log⁡S^n(t)+Λ^n(t)∣≤4/(nc2). Consequently n{S^n−e−Λ^n}→P0. Step 4.1 also gives Λ^n−Λ=OP(n−1/2); Taylor's formula for e−x on [0,∞) then yields n(S^n−S)=−S(t)n−1/2∑iϕiΛ(t)+oP(1). Taking g(x)=e−x and derivative g′(Λ)=−S(t) in [F10] transfers the terminal normal limit, giving N(0,S(t)2σ2(t)).

6.1F2F3F4F7F8F11step 1.1step 1.2step 2.1step 4.1step 5.1algebra∎

For sufficiently large n, define the bounded predictable qn(u)=[max⁡(Yˉn(u),c/2)max⁡(Yˉn(u)−1/n,c/4)]−1. On En, ΔNn(u)=1 at event times and qn(u)=1/[Yˉn(u)(Yˉn(u)−1/n)], so n∑u≤tΔNn(u)/[Yn(u)(Yn(u)−ΔNn(u))]=∫0tqn dNˉn. The uniform convergence in [F8] implies qnYˉn→1/s0 uniformly in probability, while qn is uniformly bounded. Using step 2.1, decompose ∫qn dNˉn=∫qnYˉnλ du+n−1∫qn dMn. The first term tends to σ2(t) by boundedness and ∫λ<∞; by [F3]–[F4] the second has second moment at most n−1(8/c2)2E[A1(t)], which tends to zero. Therefore the scaled Greenwood sum tends to σ2(t), and S^n(t)2→PS(t)2 by step 5.1. Since P(En)→1 and Greenwood's formula is defined on En for large n, the zero extension agrees with the formula on an event whose probability tends to one. It follows that nV^G∘(t)→PS(t)2σ2(t), which equals Var⁡(ϕiS(t)) by step 4.1. This is a first-order variance estimate, not a finite-sample identity.

5 · Examples, counterexamples and false statements

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